• PharmMap
• Method Development for QSAR Ligand-based Virtual Screening
• Protein-Ligand Interaction as Cancer Therapeutics
• Knowledge-Based Small Molecule Conformational Sampling
• BCL::EMFitMinimize
• Protein Structure Prediction using SAXS Data
• Novel HTS Datasets composed to benchmark ligand-based QSAR Modeling

Lowe, E. W.;Ferrebee, A.; Rodriguez, A.; Conn, P.J.; Meiler, J.
3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators (2010) Bioorganic & Medicinal Chemistry Letters

Edward W. Lowe, Jr.;Nils Woetzel, Jens Meiler
Poster: GPU-accelerated artificial neural network for QSAR modeling (2011) IEEE Conference

Nils Woetzel;Edward W. Lowe, Jr., Jens Meiler
Poster: GPU-accelerated rigid body fitting of atomic structures into electron density maps (2011) IEEE Conference

Mariusz Butkiewicz;Edward W. Lowe, Jr., Jens Meiler
Bcl::ChemInfo - Qualitative Analysis Of Machine Learning Models For Activation Of HSD Involved In Alzheimer’s Disease (2012) Proceedings of 2012 IEEE Symposium on Computational Intelligence and Computational Biology

Edward W. Lowe, Jr.;Mariusz Butkiewicz, Zollie White III, Matthew Spellings, Albert Omlor, Jens Meiler
Comparative Analysis of Machine Learning Techniques for the Prediction of the DMPK Parameters Intrinsic Clearance and Plasma Protein Binding (2012) Proceedings of 4th International Conference on Bioinformatics and Computational Biology 2012

Edward W. Lowe, Jr.;Mariusz Butkiewicz, Nils Woetzel, Jens Meiler
GPU-Accelerated Machine Learning Techniques Enable QSAR Modeling Of Large HTS Data (2012) Proceedings of 2012 IEEE Symposium on Computational Intelligence and Computational Biology

Greg Sliwoski;Edward W. Lowe, Jr., Mariusz Butkiewicz, Jens Meiler
BCL::EMAS Enantioselective Molecular Asymmetry Descriptor for 3D-QSAR (2012) Molecules

E. W. Lowe;M. Butkiewicz, M. Spellings, A. Omlor and J. Meiler
Comparative Analysis of Machine Learning Techniques for the Prediction of LogP (2011) IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology

Butkiewicz M;Lowe EW, Mueller R, Mendenhall JL, Teixeira PL, Weaver CD, Meiler J.
Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database (2013) Molecules

Gregory Sliwoski;Sandeepkumar Kothiwale, Jens Meiler, and Edward W. Lowe, Jr.
Computational Methods in Drug Discovery (2013) Pharmacol Rev

Sandeepkumar Kothiwale;Corina M. Borza, Edward W. Lowe Jr, Ambra Pozzi and Jens Meiler
Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery (2014) Drug Discovery Today

Kevin K. Kumar;Edward W. Lowe, Jr., Asad A. Aboud, M. Diana Neely, Rey Redha, Joshua A. Bauer,Mihir Odak, C. David Weaver, Jens Meiler, Michael Aschner, Aaron B. Bowman
Cellular manganese content is developmentally regulated in human dopaminergic neurons (2014) Scientific Reports

Mariusz Butkiewicz;Edward W. Lowe, Jr. and Jens Meiler
Bcl::ChemInfo - Qualitative Analysis Of Machine Learning Models For Activation Of HSD Involved In Alzheimer’s Disease (2012) Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), IEEE Symposium

Edward W. Lowe;Mariusz Butkiewicz, Matthew Spellings, Albert Omlor, and Jens Meiler
Comparative Analysis of Machine Learning Techniques for the Prediction of LogP (2011) Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), IEEE Symposium

Edward W. Lowe;Mariusz Butkiewicz, Zollie White III, Matthew Spellings, Albert Omlor, and Jens Meiler
Comparative Analysis of Machine Learning Techniques for the Prediction of the DMPK Parameters Intrinsic Clearance and Plasma Protein Binding (2012) Proceedings of 4th International Conference on Bioinformatics and Computational Biology

Butkiewicz M;Wang Y, Bryant SH, Lowe EW Jr, Weaver DC, Meiler J
High-Throughput Screening Assay Datasets from the PubChem Database. (2017) Chem Inform.

Daniel Putnam;Brian E. Weiner, Nils Woetzel, Edward W. Lowe Jr., Jens Meiler
BCL::SAXS: GPU accelerated Debye method for computation of small angle X-ray scattering profiles (2015) Proteins

Daniel Putnam;Edward W. Lowe Jr, Jens Meiler
Reconstruction of SAXS Profiles from Protein Structures (2013) Computational and Structural Biotechnology Journal