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Meiler Lab Computational Chemical and Structural Biology |
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Group Members
Eric Dawson
Former Post-Doctoral Fellow
Ph.D. in Pharmacology, Vanderbilt University (2001)
eric.dawson [ at ] vanderbilt.edu
Currently:
Research Assistant Professor, Pharmacology
Director, Molecular Modeling and Informatics
Vanderbilt Program in Drug Discovery (VPDD)
Vanderbilt Specialized Chemistry Center (MLPCN)
Research Interests:
- Research Projects
- Publications
Hanson, S. M.;Dawson, E. S., Francis, D. J., Van Eps, N., Klug, C. S., Hubbell, W. L., Meiler, J., Gurevich, V. V.
A model for the solution structure of the rod arrestin tetramer (2008) Structure
Butkiewicz, M.;Mueller, R., Selic, D., Dawson, E., Meiler, J.
Application of Machine Learning Approaches on Quantitative Structure Activity Relationships (best student paper in IEEE symposium in CIBCB) (2009) In IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology; Wiese
Mueller, R.;Rodriguez, A. L.; Dawson, E. S.; Butkiewicz, M.; Nguyen, T. T.; Oleszkiewicz, S.; Bleckmann, A.; Weaver, C. D.; Lindsley, C. W.; Conn, P. J.; Meiler, J.
Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening (2010) ACS Chemical Neuroscience
Kaufmann, K. W.;Dawson, E. S.; Henry, L. K.; Field, J. R.; Blakely, R. D.; Meiler, J.
Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies (2009) Proteins
Bhave G;Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel (2011) Molecular Pharmacology
Keith Henry;Hideki Iwamoto, Julie R. Field, Kristian Kaufmann, Eric S. Dawson, Miriam T. Jacobs, Chelsea Adams, Bruce Felts, Igor Zdravkovic, Vanessa Armstrong, Steven Combs, Ernesto Solis, Gary Rudnick, Sergei Y. Noskov, Louis J. DeFelice, Jens Meiler, and Randy D. Blakely
A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport (2011) Journal of Biological Chemistry
Lebois, E.P.;Bridges, T.M.; Dawson, E.S.; Kennedy, J.P.; Xiang, Z.; Jadhav, S.B.; Yin, H.; Meiler, J.; Jones, C.K.; Conn, P.J.; Weaver, C.D.; Lindsley, C.W.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system (2010) ACS Chemical Neuroscience
Ralf Mueller;Eric S. Dawson, Colleen M. Niswender, Mariusz Butkiewicz, Corey R. Hopkins, C. David Weaver, Craig W. Lindsley, P. Jeffrey Conn, Jens Meiler
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators (2012) J Mol Model
Ralf Mueller;Eric S. Dawson, Jens Meiler, Alice L. Rodriguez, Brian A. Chauder, Brittney S. Bates, Andrew S. Felts, Jeffrey P. Lamb, Usha N. Menon, Sataywan B. Jadhav, Alexander S. Kane, Carrie K. Jones, Karen J. Gregory, Colleen M. Niswender, P. Jeffrey Conn, Christopher M. Olsen, Danny G. Winder, Kyle A. Emmitte, Craig W. Lindsley
Discovery of 2-(2-Benzoxazoyl amino)-4 Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound (2012) ChemMedChem
A model for the solution structure of the rod arrestin tetramer (2008) Structure
Butkiewicz, M.;Mueller, R., Selic, D., Dawson, E., Meiler, J.
Application of Machine Learning Approaches on Quantitative Structure Activity Relationships (best student paper in IEEE symposium in CIBCB) (2009) In IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology; Wiese
Mueller, R.;Rodriguez, A. L.; Dawson, E. S.; Butkiewicz, M.; Nguyen, T. T.; Oleszkiewicz, S.; Bleckmann, A.; Weaver, C. D.; Lindsley, C. W.; Conn, P. J.; Meiler, J.
Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening (2010) ACS Chemical Neuroscience
Kaufmann, K. W.;Dawson, E. S.; Henry, L. K.; Field, J. R.; Blakely, R. D.; Meiler, J.
Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies (2009) Proteins
Bhave G;Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel (2011) Molecular Pharmacology
Keith Henry;Hideki Iwamoto, Julie R. Field, Kristian Kaufmann, Eric S. Dawson, Miriam T. Jacobs, Chelsea Adams, Bruce Felts, Igor Zdravkovic, Vanessa Armstrong, Steven Combs, Ernesto Solis, Gary Rudnick, Sergei Y. Noskov, Louis J. DeFelice, Jens Meiler, and Randy D. Blakely
A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport (2011) Journal of Biological Chemistry
Lebois, E.P.;Bridges, T.M.; Dawson, E.S.; Kennedy, J.P.; Xiang, Z.; Jadhav, S.B.; Yin, H.; Meiler, J.; Jones, C.K.; Conn, P.J.; Weaver, C.D.; Lindsley, C.W.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system (2010) ACS Chemical Neuroscience
Ralf Mueller;Eric S. Dawson, Colleen M. Niswender, Mariusz Butkiewicz, Corey R. Hopkins, C. David Weaver, Craig W. Lindsley, P. Jeffrey Conn, Jens Meiler
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators (2012) J Mol Model
Ralf Mueller;Eric S. Dawson, Jens Meiler, Alice L. Rodriguez, Brian A. Chauder, Brittney S. Bates, Andrew S. Felts, Jeffrey P. Lamb, Usha N. Menon, Sataywan B. Jadhav, Alexander S. Kane, Carrie K. Jones, Karen J. Gregory, Colleen M. Niswender, P. Jeffrey Conn, Christopher M. Olsen, Danny G. Winder, Kyle A. Emmitte, Craig W. Lindsley
Discovery of 2-(2-Benzoxazoyl amino)-4 Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound (2012) ChemMedChem