Group Members

Diego del Alamo

Current Graduate Student

BS in Biochemistry, University of New Hampshire, USA
del.alamo [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite

Research Interests:

• Structure prediction and modeling from sparse data
• Supplementing membrane protein folding algorithms with structural biology data
• Running experimental EPR measurements on transporter proteins

Co-mentored by Dr. Hassane Mchaourab (Mchaourab Lab)

Project Description:

I am writing methods in Rosetta for modeling conformational heterogeneity using sparse EPR spectroscopy data. EPR measures nanometer-scale distances under equilibrium conditions, and can be used to monitor conformational changes in protein structures. I am applying these methods to membrane transporter proteins with two goals in mind. First, I would like to improve our understanding of substrate-dependent alternating access. Second, I would like to model transient conformations that may be difficult to structurally characterize using other methods.