Group Members

Laura Friggeri

Current Post-Doctoral Fellow

PhD in Pharmaceutical Sciences, Sapienza University of Rome, Italy
laura.friggeri [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite

Research Interests:

• Small molecule drug discovery
• Organic synthesis
• Hit to Lead optimization
• Structured-based drug design
• SB-CADD
• LB-CADD

Collaboration with Prof. Craig W. Lindsley

Project Description:

I am working to develop novel chemotypes targeting allosteric binding pockets of GPCRs, particularly the class C metabotropic glutamate receptors (mGluRs) by combining computational methods such as structure-based computer aided drug discovery (SB-CADD), ligand-based computer aided drug discovery (LB-CADD), and chemical synthesis. Integration of structural models with small molecule structure-activity relationship data can help us identify novel scaffolds with a focus on drug-like properties (solubility, absorption, metabolism, etc.) to be applied to new biological targets.

Publication Link:

https://www.ncbi.nlm.nih.gov/myncbi/1tyFvkNlcUCIeY/bibliography/public/