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IDProjectCategoryView StatusDate SubmittedLast Update
0000354Rosetta[All Projects] Incorrect Resultspublic2014-10-21 12:582014-10-21 12:58
Assigned To 
PlatformAll platformsOSAnyOS VersionAny
Product VersionTrunk 
Fixed in Version 
Summary0000354: Missing residues from ROSIE antibody modeling
DescriptionA user used the antibody modeling apps through ROSIE and had two residues missing in the final antibody structure. [^]

From conversations with people more knowledgeable than I in regards to the antibody suite, it most likely has to do with the framework that was chosen from the input sequence.

In cases like these, the antibody modeling script could call the partial_thread application and then the hybridize comparative modeling application to create the full structure of the antibody without the CDRs. This may be difficult as hybridize may try to connect the CDR stems. Perhaps a call to Remodel would be sufficient to add the missing residues.
TagsNo tags attached.
Application(s) AffectedAntibody modeling suite - script application, ROSIE
Command Line UsedROSIE antibody modeling
Developer Options
Fixed in SVN Version
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Date Modified Username Field Change
2014-10-21 12:58 jadolfbr New Issue

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