MantisBT - Rosetta
View Issue Details
0000354Rosetta[All Projects] Incorrect Resultspublic2014-10-21 12:582014-10-21 12:58
jadolfbr 
 
normalminoralways
newopen 
All platformsAnyAny
Trunk 
 
Antibody modeling suite - antibody.py script application, ROSIE
ROSIE antibody modeling
0000354: Missing residues from ROSIE antibody modeling
A user used the antibody modeling apps through ROSIE and had two residues missing in the final antibody structure.

https://www.rosettacommons.org/node/3769 [^]

From conversations with people more knowledgeable than I in regards to the antibody suite, it most likely has to do with the framework that was chosen from the input sequence.

In cases like these, the antibody modeling script could call the partial_thread application and then the hybridize comparative modeling application to create the full structure of the antibody without the CDRs. This may be difficult as hybridize may try to connect the CDR stems. Perhaps a call to Remodel would be sufficient to add the missing residues.
No tags attached.
Issue History
2014-10-21 12:58jadolfbrNew Issue

There are no notes attached to this issue.